Table 3 Risk factors for mortality and ovarian cancer recurrence – multivariate analysis in type I vs type II ovarian cancer patients

From: Role of histological type on surgical outcome and survival following radical primary tumour debulking of epithelial ovarian, fallopian tube and peritoneal cancers

  In tumour stages 1 and 2 In tumour stages 3 and 4
Variable HR 95% CI P -value HR 95% CI P -value
Mortality
 No ascitesa (vs any) 0.33 0.002–0.48 0.013 1.07 0.661–1.72 0.79
 Ascites <500 mla (vs >500 ml) 0.036 0.004–0.331 0.003 0.87 0.61–1.24 0.46
 N1 (vs N0) 110.87 6.78–1812 0.001 2.63 1.73–4 <0.001
 Any tumour residuals (vs none) 11.64 0.57–238.04 0.11 1.95 1.35–2.8 <0.001
 High-grade serous (vs low-grade serous) 0.88 0.033–23.87 0.94 2.5 0.6–10.6 0.17
 Mucinous (vs low-grade serous) 0.28 0.004–20.84 0.56 5.4 1.12–26.06 0.03
 Clear cell (vs low-grade serous) 3.09 0.14–68.8 0.476 4.07 0.34–48.2 0.27
 Age >65 years (vs <65 years) 0.14 0.002–11.95 0.38 1.4 0.98–2.001 0.06
 >4 IMO fields tumour involved (vs <4) 2.02 0.065–62.53 0.69 1.42 0.99–2.03 0.052
 Other types I (vs low-grade serous) 0.000 0.000– 0.99 0.00 0.000– 0.95
 Other types II (vs low-grade serous) 1.206 0.053–27.57 0.91 3.62 0.8–16.4 0.09
Ovarian cancer relapse
 No ascites (vs any) 0.15 0.03–0.81 0.028 1.2 0.82–1.8 0.32
 Ascites <500 ml (vs >500 ml) 0.12 0.02–0.67 0.015 0.86 0.63–1.17 0.33
 N1 (vs N0) 11.37 2.02–64.1 0.006 1.88 1.32–2.69 0.001
 Any tumour residuals (vs none) 3.96 0.43–35.92 0.221 1.66 1.2–2.27 0.002
 High-grade serous (vs low-grade serous) 1.59 0.12–20.76 0.22 2.34 0.84–6.53 0.10
 Mucinous (vs low-grade serous) 0.29 0.015–6.02 0.43 2.54 0.75–8.6 0.13
 Clear cell (vs low-grade serous) 4.83 0.31–75.1 0.26 4.6 0.79–27.12 0.09
 Age >65 years (vs <65 years) 0.53 0.082–3.48 0.51 1.11 0.81–1.5 0.49
 Other types I (vs low-grade serous) 0.000 0.000– 0.99 0.61 0.066–5.6 0.66
 Other types II (vs low-grade serous) 4.64 0.46–47.07 0.19 2.06 0.68–6.3 0.2
  1. Abbreviations: CI=confidence interval; HR=hazard ratio; IMO=Intraoperative Mapping of Ovarian Cancer.
  2. Variables are compared stage-by-stage (1/2 and 3/4) between the different histologies.
  3. aAscites with significant protective effect. Bold values are statistically significant, i.e. P<0.05.