Table 4 Multivariate Cox regression analysis of 8-year RFS and OS

From: The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study

  8-year RFS 8-year OS
  HR 95% CI P HR 95% CI P
CatS expression 1.81 1.17–2.82 0.08 1.47 0.96–2.26 0.08
Treatment status 1.25 0.59–2.66 0.56 1.22 0.57–2.61 0.60
Treatment status CatS expressiona 0.46 0.24–0.90 0.02 0.49 0.50–0.96 0.04
Stage 3.12 1.96–4.95 <0.001 2.79 1.72–4.53 <0.001
LVI (yes vs no/NOS) 1.90 1.19–3.03 0.007 2.04 1.24–3.35 0.005
Tumour site (proximal vs distal)b 2.00 1.11–3.61 0.02 2.00 1.08–3.71 0.03
Tumour site (rectal vs distal)b 2.36 1.28–4.36 0.006 2.10 1.11–3.96 0.03
  1. Abbreviations: CatS=Cathepsin S; CI=confidence interval; HR=hazard ratio; LVI=lymphovascular invasion; NOS=not otherwise specified; OS=overall survival; RFS=recurrence-free survival.
  2. The tumour site was considered as a categorical variable comparing proximal and rectal locations to distal. Three cases of synchronous location were excluded from the model.
  3. aInteractive term for CatS expression and treatment status.
  4. bProximal: caecum, ascending colon, hepatic flexure, transverse colon; distal: descending colon, sigmoid colon; rectal: rectosigmoid, rectum.