Table 2 Association of CatS expression with clinicopathological features

From: The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study

   Antigen expression level  
  n (%) Low (%) Moderate (%) High (%) P
Grade 539     
 Well differentiated (I) 46 (8) 16 (35) 17 (37) 13 (28)  
 Moderately differentiated (II) 403 (75) 142 (35) 180 (45) 81(20) 0.005a
 Poorly differentiated (III) 90 (17) 46 (51) 32 (36) 12 (13)  
Stage (TNM) 558     
 I 22 (4) 13 (59) 7 (32) 2 (9)  
 II 318 (57) 120 (38) 141 (44) 57 (18) 0.15a
 III 206 (37) 72 (35) 87 (42) 47 (23)  
 IV 14 (3) 7 (50) 5 (36) 2 (14)  
Tumour site c 278     
 Proximal 114 (41) 34 (30) 59 (52) 21 (18)  
 Distal 91 (33) 26 (29) 47 (51) 18 (20) 0.98b
 Rectum 73 (26) 23 (32) 35 (48) 15 (20)  
LVI status 206     
 Yes 78 (38) 23 (30) 37 (47) 18 (23) 0.53b
 No 128 (62) 37 (29) 69 (54) 22 (17)  
  1. Abbreviations: CatS=Cathepsin S; LVI=lymphovascular invasion.
  2. Association of CatS with disease stage and tumour grade was assessed in all cohorts. In all, 20 cases of unknown grade were removed from the grade analysis. Association of CatS with tumour site and LVI status was assessed in the Beaumont Hospital and NI Cancer Centre cohorts only. Three cases of synchronous location were removed in the tumour site analysis and 55 cases of unknown LVI status were removed from the LVI analysis.
  3. aCalculated P-values are from ordinal regression.
  4. bCalculated P-values are from Pearson's χ2-tests.
  5. cProximal: caecum, ascending colon, hepatic flexure, transverse colon; distal: descending colon, sigmoid colon; rectal: rectosigmoid colon, rectum.