Figure 1 | British Journal of Cancer

Figure 1

From: The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study

Figure 1

Representative images of CatS expression patterns in cell lines and patient samples. CatS-specific staining is brown and nuclear counterstaining is blue. (A) Parental CHO- and CatS-CHO-overexpressing cell lines where CatS-specific staining is evident in the overexpressing line only. (B) Normal colonic mucosa, where a finely granular pattern is observed; and in colorectal carcinoma and lymph node metastatic tissue, where an increase in expression is evident. (C) Distinct patterns of expression were observed in tumours such as basal epithelial polarisation, indicated with arrow heads; loss of expression concomitant with loss of differentiation, indicated with arrows; and intense CatS expression in tumour-associated cells, indicated with arrow heads. The scale can be found on images.

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