Abstract
The precise mechanism of fever and flu-like syndrome that occurs in treatment with deoxycytidine analogues remains unclear. This study demonstrated a strong correlation between plasma interleukin 6 levels and fever in treatment with oral (E)-2'-deoxy-2'(fluoromethylene)cytidine, another deoxycytidine analogue.
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Masuda, N., Negoro, S., Takeda, K. et al. Interleukin 6 is a cause of flu-like symptoms in treatment with a deoxycytidine analogue. Br J Cancer 78, 388–389 (1998). https://doi.org/10.1038/bjc.1998.504
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DOI: https://doi.org/10.1038/bjc.1998.504