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CODE chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer

British Journal of Cancer volume 75, pages 306–309 (1997)Cite this article

Abstract

Sixty-three patients with extensive-stage small-cell lung cancer were randomized to receive either cyclophosphamide, vincristine, doxorubicin and etoposide (CODE) alone or CODE plus recombinant human granulocyte colony-stimulating factor (rhG-CSF). rhG-CSF administration in support of CODE chemotherapy resulted in increased mean total received dose intensity for all drugs (P = 0.03) with a significant improvement in survival (P = 0.004).

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Authors and Affiliations

  1. Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan

    M Fukuoka

Authors
  1. M Fukuoka
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  2. N Masuda
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  3. S Negoro
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  4. K Matsui
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  5. T Yana
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  6. S Kudoh
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  7. Y Kusunoki
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  8. M Takada
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  9. M Kawahara
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  10. M Ogawara
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  11. N Kodama
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  12. K Kubota
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  13. K Furuse
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Fukuoka, M., Masuda, N., Negoro, S. et al. CODE chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer. Br J Cancer 75, 306–309 (1997). https://doi.org/10.1038/bjc.1997.50

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  • DOI: https://doi.org/10.1038/bjc.1997.50

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