Abstract
Organ transplant recipients receiving immunosuppression show a dramatically increased risk of non-melanoma skin cancer. The cause of this increase is not known. We report that the rate of loss of heterozygosity (at all the loci we examined) was significantly lower in tumours from immunosuppressed individuals than in tumours from immunocompetent subjects [20 out of 148 (14%) vs 157 out of 428 (37%); P< 0.0001]. These results suggest that tumours in immunosuppressed individuals have a different molecular pathogenesis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rehman, I., Quinn, A., Takata, M. et al. Low frequency of allelic loss in skin tumours from immunosuppressed individuals. Br J Cancer 76, 757–759 (1997). https://doi.org/10.1038/bjc.1997.457
Issue Date:
DOI: https://doi.org/10.1038/bjc.1997.457
This article is cited by
-
Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients
BMC Cancer (2013)
-
Single Nucleotide Polymorphism Array Analysis Defines a Specific Genetic Fingerprint for Well-Differentiated Cutaneous SCCs
Journal of Investigative Dermatology (2009)
