Clinical Oncology/Epidemiology

Cigarette smoking and urinary oestrogen excretion in premenopausal and post-menopausal women

Abstract

Cigarette smoking is associated with a reduction in the risk for endometrial cancer in post-menopausal women and it has been suggested that this is because smoking has an anti-oestrogenic effect. To investigate this, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 167 premenopausal women (53 smokers, 114 non-smokers) and 200 post-menopausal women (54 smokers, 146 non-smokers). Among premenopausal women there were no significant differences in oestrogen excretion between smokers and non-smokers. Among post-menopausal women, geometric mean excretion rates for oestrone and oestradiol did not differ significantly between groups, but oestriol excretion was 19% lower (95% confidence interval -34% to -1%) in smokers than in non-smokers. This may partly explain the reduced risk for endometrial cancer among post-menopausal smokers.

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Key, T., Pike, M., Brown, J. et al. Cigarette smoking and urinary oestrogen excretion in premenopausal and post-menopausal women. Br J Cancer 74, 1313–1316 (1996). https://doi.org/10.1038/bjc.1996.536

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