Clinical Oncology/Epidemiology

Birth characteristics and risk of Wilms' tumour: a nationwide prospective study in Norway

Abstract

Relationships between incidence of Wilms' tumour and information recorded at birth were investigated in a prospective study of the 1,489,297 children born in Norway between 1967 and 1992. A total of 119 individuals were diagnosed with Wilms' tumour in the age interval 0-14 years. A high length at birth was significantly associated with a high risk (incidence rate ratio 1.8 for length > or = 53 cm vs < or = 49 cm, 95% CI 1.0-3.2). A low Apgar score at 1 min was also associated with an increased risk (incidence rate ratio 2.2 for Apgar score < or = 8 vs a score > or = 9, 95% CI 1.2-3.9). For all variables for which an association was indicated, the association seemed to be restricted mainly to children aged less than 2 years. This suggests that Wilms' tumour diagnosed early in life may differ aetiologically from that of cases diagnosed later.

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Heuch, J., Heuch, I. & Kvåle, G. Birth characteristics and risk of Wilms' tumour: a nationwide prospective study in Norway. Br J Cancer 74, 1148–1151 (1996) doi:10.1038/bjc.1996.505

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