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Clinical Oncology/Epidemiology

Influence of smoking in the glutathione-S-transferase M1 deficiency - associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt

Abstract

In this study we show an effect of the glutathione-S-transferase M1 (GSTM1) null phenotype on the risk for squamous cell carcinoma (SCC) of the bladder among male smokers in Egypt, with an adjusted odds ratio of 4.8 (95% confidence interval: 1.06-21.77). However, no overall effect of the GSTM1 null phenotype on the risk for bladder SCC was observed.

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Lafuente, A., Zakahary, M., el-Aziz, M. et al. Influence of smoking in the glutathione-S-transferase M1 deficiency - associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt. Br J Cancer 74, 836–838 (1996). https://doi.org/10.1038/bjc.1996.445

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