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  • Clinical Oncology/Epidemiology
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Clinical Oncology/Epidemiology

Final report of a phase II study of interleukin 2 and interferon α in patients with metastatic melanoma

British Journal of Cancer volume 71, pages 1319–1321 (1995)Cite this article

Abstract

Fifty-seven patients with metastatic melanoma were treated with interleukin 2 (IL-2) 7.8 MIU m-2 day-1 as a continuous infusion for 4 days combined with interferon alpha (IFN-alpha) 6 MIU m-2 day-1 subcutaneously on days 1 and 4. The cycle was repeated every 2 weeks for a maximum number of 13 cycles. Of the 51 evaluable patients, one (2%) achieved a complete and seven (14%) a partial response (total response rate 16%; CI 7-29%). Median time to progression and median survival were 2.5 and 11.3 months respectively. This regimen of IL-2 and IFN-alpha appeared to be only moderately active.

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Authors and Affiliations

  1. Department of Medical Oncology, Rotterdam Cancer Institute, The Netherlands

    WHJ Kruit

Authors
  1. WHJ Kruit
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  2. SH Goey
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  3. F Calabresi
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  4. A Lindemann
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  5. RA Stahel
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  6. H Poliwoda
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  7. B Osterwalder
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  8. G Stoter
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Kruit, W., Goey, S., Calabresi, F. et al. Final report of a phase II study of interleukin 2 and interferon α in patients with metastatic melanoma. Br J Cancer 71, 1319–1321 (1995). https://doi.org/10.1038/bjc.1995.256

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  • DOI: https://doi.org/10.1038/bjc.1995.256

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