Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis

Abstract

A lipopolysaccharide (BP-LPS) isolated from killed Bordetella pertussis (Tohama strain) was determined to have low toxicity based on the mortality and decrease in body weight of BP-LPS-injected mice. BP-LPS, administered intradermally or intraperitoneally, clearly inhibited the growth of an MM46 murine mammary carcinoma. When compared with a toxic Escherichia coli-derived LPS, BP-LPS displayed excellent anti-tumour activity against MH134 hepatoma and Meth A fibrosarcoma. As part of a combined chemotherapy/immunotherapy regimen, BP-LPS also seemed to prolong the lifespan of mice inoculated with Lewis lung carcinoma. BP-LPS thus appears to have valuable characteristics as an anti-tumour agent.

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Ohnishi, M., Kimura, S., Yamazaki, M. et al. Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis. Br J Cancer 69, 1038–1042 (1994) doi:10.1038/bjc.1994.204

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