Abstract
A hospital-based case-control study was undertaken to examine the role of human papillomavirus (HPV) in the development of invasive cervical cancer in Brazil. The study included 199 histologically confirmed incident cases and 225 age-frequency-matched controls selected from a wide range of diagnostic categories. A polymerase chain reaction technique was used to detect HPV DNA in cervical specimens collected with spatula and brush. HPV DNA was detected in 84% of the cases compared with 17% of controls. Grouping HPV types 16, 18, 31 and 33, 66% of the cases were positive compared with only 6% of the controls. In addition to HPV, number of sexual partners, early age at first intercourse, parity and duration of oral contraceptive use were significantly associated with an increased risk of cervical cancer. A history of previous Papanicolaou smears was significantly associated with a decreased risk. After adjustment, only presence of HPV DNA, parity and history of previous smears remained as independent risk factors. The adjusted odds ratios of cervical cancer associated with HPV 16, 18, 31, and 33 was 69.7 (95% confidence interval 28.7-169.6) and with unidentified types was 12.0 (5.1-28.5). The very high risks found in this study further implicate this virus in the aetiology of cervical cancer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eluf-Neto, J., Booth, M., Muñoz, N. et al. Human papillomavirus and invasive cervical cancer in Brazil. Br J Cancer 69, 114–119 (1994). https://doi.org/10.1038/bjc.1994.18
Issue Date:
DOI: https://doi.org/10.1038/bjc.1994.18
This article is cited by
-
HPV genotype distribution in Brazilian women with and without cervical lesions: correlation to cytological data
Virology Journal (2016)
-
Humane Papillomaviren
Der Gynäkologe (2016)
-
Herpes simplex virus type 2 and the risk of cervical cancer: a meta-analysis of observational studies
Archives of Gynecology and Obstetrics (2014)
-
Human papillomavirus genotypes distribution in 175 invasive cervical cancer cases from Brazil
BMC Cancer (2013)
-
Prevalence of human papillomavirus in archival samples obtained from patients with cervical pre-malignant and malignant lesions from Northeast Brazil
BMC Research Notes (2010)