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  • Experimental Oncology
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Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours

British Journal of Cancer volume 68, pages 460–464 (1993)Cite this article

Abstract

Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas.

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Authors and Affiliations

  1. Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del CNR, II Facoltà di Medicina e Chirurgia, Università di Napoli, Italy

    M Santoro

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  1. M Santoro
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  2. N Sabino
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  3. Y Ishizaka
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  4. T Ushijima
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  5. F Carlomagno
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  6. A Cerrato
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  7. M Grieco
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  8. C Battaglia
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  9. ML Martelli
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  10. C Paulin
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  11. N Fabien
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  12. T Sugimura
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  13. A Fusco
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  14. M Nagao
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Santoro, M., Sabino, N., Ishizaka, Y. et al. Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours. Br J Cancer 68, 460–464 (1993). https://doi.org/10.1038/bjc.1993.370

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  • DOI: https://doi.org/10.1038/bjc.1993.370

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