Abstract
Six hundred and eighty-four primary breast cancers from the International (Ludwig) Breast Cancer Study Group (IBCSG) were studied for Helix pomatia lectin (HPA) binding. There was a weak correlation between lymph node-positive and HPA positive (P = 0.04). In our series there was a large advantage in disease-free survival (DFS) and overall survival (OS) for node-negative patients (P < 0.0001 DFS and OS). However, there was no such advantage for HPA-negative patients (P = 0.23 DFS and P = 0.32 OS). We conclude that in this randomised patient group HPA is of no clinical predictive value.
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International (Ludwig) Breast Cancer Study Group Writing Committee: B.A. Gusterson, C.W. Taylor, K.N. Price, R.D. Gelber, J. Save-S6derbergh, R. Anbazhagan, H. Jayatilake, C.-M. Rudenstam, R. Reed, L. Morassi, P. Grigolato, M., Zorzi, R. Bettelheim, A.M. Neville, G.C. Hitchcock, M. Jagush, A. Tiltman, H.G. Schniirch, H. Bender, R. Golouh, J. Lamovec, J. Jancar, F. Martinez-Tello, K.B. Shilkin, G. Locher, K. Biirki, M. Stanisic, Th. Hardmeier, P. Luscieti, E. Passega, J. Torhorst, R.P. Baumann, E. Jacot-des-Coombes, P. Anani, A. Ng, M. Castiglione, H.-J. Senn & A. Goldhirsch. Other members of the Group are listed in the Appendix.. Prognostic value of Helix pomatia in Breast Cancer. Br J Cancer 68, 146–150 (1993). https://doi.org/10.1038/bjc.1993.303
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DOI: https://doi.org/10.1038/bjc.1993.303
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