Abstract
Overexpression of the tumour suppressor gene p53 was investigated immunohistochemically in 96 primary gastric carcinomas and 26 corresponding metastatic perigastric lymph nodes. Abnormalities in p53 expression were found in 52 (54%) of the 96 primary carcinomas. Tumours stained positively for p53 frequently metastasised to lymph nodes (the metastatic rate: 85%) compared to findings in those with negative p53 staining (64%, P < 0.05). Ninety-two percent (24/26) of the malignant cells in the lymph nodes stained positively for p53. When the DNA ploidy pattern of the tumour was determined by flow cytometry, the aneuploid tumours in p53 positive and negative groups accounted for 69% and 45%, respectively (P < 0.05). Proliferative activity of the tumour, as measured by Ki-67 labelling, was significantly higher (30.6 +/- 12.0%) in the p53 positive group than that (25.1 +/- 10.7%) in the p53 negative group (P < 0.05). Thus, gastric cancer with a mutant p53 has high proliferative activity and metastasis to lymph nodes will probably occur.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kakeji, Y., Korenaga, D., Tsujitani, S. et al. Gastric cancer with p53 overexpression has high potential for metastasising to lymph nodes. Br J Cancer 67, 589–593 (1993). https://doi.org/10.1038/bjc.1993.108
Issue Date:
DOI: https://doi.org/10.1038/bjc.1993.108
This article is cited by
-
Intestinal-type gastric dysplasia in Helicobacter pylori-naïve patients
Virchows Archiv (2022)
-
Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study
Gastric Cancer (2021)
-
Prognostic Significance of p53 Protein Expression in Early Gastric Cancer
Pathology & Oncology Research (2011)
-
Prognostic value of p53 protein and MK-1 (a tumor-associated antigen) expression in gastric carcinoma
Gastric Cancer (2007)
-
p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer
British Journal of Cancer (2004)