Abstract
In this report, we investigate several examples of hypoxia-induced drug resistance and compare them with P-glycoprotein associated multidrug resistance (MDR). EMT6/Ro cells exposed to drugs in air immediately after hypoxic treatment developed resistance to adriamycin, 5-fluorouracil, and actinomycin D. However, these cells did not develop resistance to colchicine, vincristine or cisplatin. When the cells were returned to a normal oxygen environment, they lost resistance. There was no correlation between the content of adriamycin and the development of adriamycin resistance induced by hypoxia. There was no difference between the efflux of adriamycin from aerobic cells and that from hypoxia-treated cells. The mRNA for P-glycoprotein was not detected in the hypoxia-treated cells. These results suggest that hypoxia-induced drug resistance is different from P-glycoprotein associated multidrug resistance.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sakata, K., Kwok, T., Murphy, B. et al. Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance. Br J Cancer 64, 809–814 (1991). https://doi.org/10.1038/bjc.1991.405
Issue Date:
DOI: https://doi.org/10.1038/bjc.1991.405
This article is cited by
-
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Signal Transduction and Targeted Therapy (2023)
-
High expression of TMEM180, a novel tumour marker, is associated with poor survival in stage III colorectal cancer
BMC Cancer (2021)
-
Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer
BMC Cancer (2015)
-
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
Cancer Cell International (2015)
-
Effects of hypoxia on human cancer cell line chemosensitivity
BMC Cancer (2013)