Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Investigations of tissue folates in normal and malignant tissues

British Journal of Cancer volume 47, pages 393–398 (1983)Cite this article

Abstract

The folates present in liver, gut and tumour tissue were examined before and after autolysis. Before autolysis 10-formylfolate tetraglutamate (10-CHOFA(glu)4), 5-methyltetrahydrofolate triglutamate (5-CH3THF(glu)3) and possibly tetrahydrofolate polyglutamate(s) (THF(glu)n) were detected. Liver contained all 3 species whereas no 5-CH3THF(glu)3 was present in the tumours, gut showed an intermediate situation. After autolysis the predominant monoglutamates formed were 5-CH3THF in the liver, 10-formylfolates in the gut and possibly tetrahydrofolate (THF) in the tumour extracts. These differences illustrate changes in tissue folates with the proliferation rate of the tissue and suggest an explanation for the methionine auxotrophy of Walker 256 carcinosarcoma cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Authors
  1. A E Pheasant
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Bates
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J A Blair
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R Nayyir-Mazhir
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pheasant, A., Bates, J., Blair, J. et al. Investigations of tissue folates in normal and malignant tissues. Br J Cancer 47, 393–398 (1983). https://doi.org/10.1038/bjc.1983.59

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/bjc.1983.59

Search

Advanced search

Quick links