Abstract
In mice with a transplantable mammary carcinoma, treatment with the prostaglandin-synthesis inhibitors flurbiprofen or indomethacin produced various beneficial effects. Survival time after excision of the transplanted tumour was increase, particularly when the drugs were given with the chemotherapeutic agents methrotrexate and melphalan, and there were more disease-free survivors. The combined treatment with flurbiprofen also gave less tumour recurrence at the excision site. Flurbiprofen did not seem to alter the bioavailability of the chemotherapeutic agents.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Bennett, A., Berstock, D. & Carroll, M. Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy. Br J Cancer 45, 762–768 (1982). https://doi.org/10.1038/bjc.1982.118
Issue Date:
DOI: https://doi.org/10.1038/bjc.1982.118
This article is cited by
-
Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer
Diseases of the Colon & Rectum (1984)
-
Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin
Journal of Cancer Research and Clinical Oncology (1983)