Abstract
The macrophage content of cell suspensions from naturally occurring mouse tumours has been assessed by the Fc-mediated phagocytosis assay, and the results compared with the individual tumour's capacity for spontaneous metastasis and with its pulmonary colonization potential after i.v. inoculation. It was found that these tumours differ in their properties from the transplantable fibrosarcomas studied previously by other investigators, in that the macrophage content of all the tumours was uniformly low, ranging from 2 to 9% (mean 4.2 +/- 1.8%) and there was no inverse correlation with frequency of spontaneous metastasis, which was low. When the tumours were inoculated i.v. there was also no correlation with colony-forming capability, which varied greatly between tumours. Lung secondary deposits contained 1.7-6% macrophages (mean 4.4 +/- 0.6%) with a lower phagocytic activity for antibody-coated red cells than in the primary tumour.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Nash, J., Price, J. & Tarin, D. Macrophage content and colony-forming potential in mouse mammary carcinomas. Br J Cancer 43, 478–485 (1981). https://doi.org/10.1038/bjc.1981.70
Issue Date:
DOI: https://doi.org/10.1038/bjc.1981.70
This article is cited by
-
Clinical and Biological Implications of the Tumor Microenvironment
Cancer Microenvironment (2012)
-
Inflammatory cell infiltration of tumors: Jekyll or Hyde
Cancer and Metastasis Reviews (2007)
-
Evasion of host defences by tumours
Immunology & Cell Biology (1987)
-
Relationship of macrophage content, immunogenicity, and metastatic potential of a murine osteosarcoma of recent origin
Clinical & Experimental Metastasis (1985)
-
Macrophages in cancer metastases and their relevance to metastatic growth
CANCER AND METASTASIS REVIEW (1983)