Combination therapy of a mouse sarcoma using razoxane and electron irradiation

Abstract

The combination of a single dose of razoxane (ICRF 159) with a single dose of electron radiation has been studied with the murine sarcoma S180. A drug dose of 30 mg/kg combined with radiation produced a greater tumour response than either agent alone, but it was not possible to establish whether the effect was more than additive. Direct measurements of tumour and s.c. oxygen concentrations and studies of tumour-cell respiration were carried out after various razoxane treatments in an attempt to elucidate mechanisms of action. There were no indications at the drug dose levels used in the radiation studies of any significant changes in tissue oxygenation or cellular respiration.