Abstract
In a group of 74 patients with advanced metastatic breast cancer, 57% of those with cytoplasmic oestrogen receptor activity in their tumours (REC+) showed a clinical response to endocrine therapy. Of 51 patients whose tumour was assayed for both REC and cytoplasmic progesterone (RPC) activity, 9/12 patients with REC+ RPC+ tumours responded to hormone treatment, whereas only 3/30 patients with REC-RPC-tumours had a clinical response. In a group of 19 patients in whom nuclear oestrogen receptor (REN) was also estimated in the pellets from tumour-tissue homogenates, 5/6 with tumours positive for all 3 receptors showed a clinical response. None of the 9 patients with triply negative tumours responded. Addition of the REN assay appears to reinforce the greater precision of prediction when RPC as well as REC are estimated in breast tumours.
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Barnes, D., Skinner, L. & Ribeiro, G. Triple hormone-receptor assay: a more accurate predictive tool for the treatment of advanced breast cancer?. Br J Cancer 40, 862–865 (1979). https://doi.org/10.1038/bjc.1979.277
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DOI: https://doi.org/10.1038/bjc.1979.277
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