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Malignant neoplasms in rats fed lasiocarpine

British Journal of Cancer volume 37, pages 289–293 (1978)Cite this article

Abstract

Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.

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Authors
  1. M S Rao
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  2. J K Reddy
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Rao, M., Reddy, J. Malignant neoplasms in rats fed lasiocarpine. Br J Cancer 37, 289–293 (1978). https://doi.org/10.1038/bjc.1978.38

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  • DOI: https://doi.org/10.1038/bjc.1978.38

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