Abstract
The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements of the level of CEA and hepatic enzymes during the monitoring of postoperative patients. There is considerable stability in the profile in a given individual in health, Rises of AAT and AGP are associated with metastases. High levels of HPT may suggest involvement of the bowel wall by recurrent cancer. PALB levels tend to reflect the nutritional status. A discriminant function based on the log CEA, AAT and AGP preoperative blood levels can considerably improve on the predictive value attained using CEA levels alone.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Ward, A., Cooper, E., Turner, R. et al. Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes. Br J Cancer 35, 170–178 (1977). https://doi.org/10.1038/bjc.1977.24
Issue Date:
DOI: https://doi.org/10.1038/bjc.1977.24
This article is cited by
-
Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls
BMC Cancer (2014)
-
Immunosuppressive acidic protein serum levels in breast cancer patients in a reference to CA 15-3 levels
Breast Cancer Research and Treatment (1994)
-
Immunological studies of patients with tumours of the prostate and bladder
International Urology and Nephrology (1983)