Abstract
Slices of human prostatic adenocarcinoma obtained by transurethral resection were maintained in organ culture for 4 days. Preservation of histological appearance was good with little evidence of necrosis within the viable tissue. Slices of tumour cultured in the presence of testosterone showed a morphological change to a more differentiated type of neoplasm whereas explants cultured in the absence of steroid hormone, or with stilboestrol diphosphate, showed no change. In the case of a relatively anaplastic tumour, testosterone produced a significant increase in the number of mitotic figures seen.
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McMahon, M., Butler, A. & Thomas, G. Morphological Responses of Prostatic Carcinoma to Testosterone in Organ Culture. Br J Cancer 26, 388–394 (1972). https://doi.org/10.1038/bjc.1972.51
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DOI: https://doi.org/10.1038/bjc.1972.51
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