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Immunofluorescent Localisation of Human Alpha Fetoprotein in Fetal and Neonatal Livers and Cultured Cells from Hepatocellular Carcinoma

British Journal of Cancer volume 25, pages 343–349 (1971)Cite this article

Abstract

The indirect immunofluorescence technique demonstrated that human alpha fetoprotein (AFP) was present in a focal pattern in the cytoplasm of malignant liver cells of patients whose sera contained AFP. A few fibroblastlike cells in tissue culture of liver biopsies from patients with hepato-cellular carcinoma and AFP in their sera also had the protein. The intracellular localisation of human AFP was confirmed by centrifugation of washed, homogenised and ultra-sonically disrupted neonatal liver cells. Examination of livers of fetuses and neonates showed that AFP was present predominantly in the periportal parenchymal cells.

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Authors
  1. J A Smith
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  2. T I Francis
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  3. G M Edington
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  4. A O Williams
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Smith, J., Francis, T., Edington, G. et al. Immunofluorescent Localisation of Human Alpha Fetoprotein in Fetal and Neonatal Livers and Cultured Cells from Hepatocellular Carcinoma. Br J Cancer 25, 343–349 (1971). https://doi.org/10.1038/bjc.1971.44

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  • DOI: https://doi.org/10.1038/bjc.1971.44

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