Table 4 Intrinsic risk factors for disease transformation in PV and ET

From: Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors

Transformation Clinical risk factors Genetic risk factors
Post-PV MF Age JAK2V617F allele burden
  Leukocytosis  
  Disease duration  
  Reticulin fibrosis  
  Splenomegaly  
Post-PV Leukemia Age Abnormal karyotype
  Leukocytosis TP53
  Reticulin fibrosis RUNX1
  Splenomegaly  
Post-ET MF Age Absent JAK2V617F mutation
  Leukocytosis ASXL1
  Anemia  
  Reticulin fibrosis  
Post-ET leukemia Age TP53
  Leukocytosis RUNX1
  Anemia  
  Reticulin fibrosis  
  Thrombosis  
  Platelets 1000 × 109/l  
  1. Abbreviations: ET, essential thrombocythemia; MF, myelofibrosis; PV, polycythemia vera.