Figure 3 | Blood Cancer Journal

Figure 3

From: Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules

Figure 3

(a) RTK signaling and (b) adhesion molecule signaling. Asterisks indicate a mutation. Asterisks in red (bold): mutated in at least one primary MM (including Chapman et al.5) and ‘damaging’ according to three functional predictors. Asterisks in red: mutated in 1 of the 43 primary MM (including Chapman et al.5). Asterisks in black (bold): mutated in a cell line and ‘damaging’ according to three functional predictors. Asterisks in black: mutated in at least one cell line. All mutations were confirmed by Sanger sequencing in our samples, except for MMp15. Moreover, sequence information of GRK/ADBRK1 was not evaluable. Please note that not all members of a family were validated (for details see Supplementary Table S12).

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