Figure 6 | Acta Pharmacologica Sinica

Figure 6

From: Effects of the histamine H1 receptor antagonist hydroxyzine on hERG K+ channels and cardiac action potential duration

Figure 6

Relative changes in sustained hERG currents in response to hydroxyzine in Xenopus oocytes. (A) An example recording of currents under control conditions (control) and after application of 5 μmol/L hydroxyzine (for 7 min without any intervening test pulses). (B) Relative current obtained by dividing the current in 5 μmol/L hydroxyzine by the control current shown in in panel A. Current inhibition increased with depolarization time to 56% at 2 s in this representative cell, indicating that primarily open and/or inactivated channels were blocked.

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