Figure 3 | Acta Pharmacologica Sinica

Figure 3

From: Effects of the histamine H1 receptor antagonist hydroxyzine on hERG K+ channels and cardiac action potential duration

Figure 3

The effect of hydroxyzine on hERG channels expressed in Xenopus oocytes. (A) Plot of the normalized hERG current measured at the end of the depolarizing pulse (IHERG) against pulse potential in control and hydroxyzine conditions. The maximal amplitude of the IHERG in control solution was normalized to 1. (B) Plot of the normalized tail current measured at its peak following repolarization. The peak amplitude of the tail current in control solution was normalized to 1. The control data were fitted with the following Boltzmann equation, y=1/{1+exp[(-V+V1/2)/dx]}, yielding a V1/2 of −19.2 mV. (C) Activation curves with the values normalized to their respective maximum for each concentration of hydroxyzine. n=3−5.

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