Abstract
Aim:
To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure.
Methods:
Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, KATP channel-mediated relaxation responses in the aortas and mesenteric arteries, KATP channel current, and gene expression were examined, respectively.
Results:
Blood pressure and body weight were increased in rats fed with high-fat diet. KATP channel-mediated relaxation responses, currents, and KATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats.
Conclusion:
Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure.
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Project supported by the National Natural Science Foundation of China (No 30370677).
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Fan, Lh., Tian, Hy., Ma, Aq. et al. Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure. Acta Pharmacol Sin 29, 1167–1174 (2008). https://doi.org/10.1111/j.1745-7254.2008.00810.x
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DOI: https://doi.org/10.1111/j.1745-7254.2008.00810.x
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