To study the effects of osthole on hyperlipidemic fatty liver and investigate the possible mechanisms.
A rat model with hyperlipidemic fatty liver was successfully established by feeding fatty milk for 6 weeks. The experimental rats were then treated with 5-20 mg/kg osthole for 6 weeks. The mouse hyperlipidemic model was induced by feeding fatty milk when they were treated with 10-20 mg/kg osthole for 3 weeks.
After treatment with osthole, the levels of rat serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol significantly decreased as compared with the fatty liver model group (P<0.05 or P<0.01). Hepatic weight and its coefficient, the hepatic tissue contents of TC, TG, and malondialdehyde, also significantly decreased (P<0.05 or P<0.01). In fatty milk-induced hyperlipidemic mice, the post-heparin plasma activities of lipo-protein lipase (LPL), hepatic lipase (HL), and total lipase (TL) significantly increased after treatment with 10-20 mg/kg osthole for 3 weeks (P<0.05 or P<0.01). Importantly, the histological evaluation of rat liver demonstrated that osthole dramatically decreased lipid accumulation (P<0.01).
Osthole was found to have therapeutic effects on fatty milk-induced rat fatty liver; the mechanisms might be associated with its anti-oxidation and the elevation of the activities of LPL and HL.
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Project supported by the “Three Medicines” tackle Key Problems in Science and Technology Foundation of Suzhou, China (No SSY0608)
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Zhang, Y., Xie, Ml., Zhu, Lj. et al. Therapeutic effect of osthole on hyperlipidemic fatty liver in rats. Acta Pharmacol Sin 28, 398–403 (2007). https://doi.org/10.1111/j.1745-7254.2007.00533.x
- hyperlipidemic fatty liver
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