Discovery and development of sulforaphane as a cancer chemopreventive phytochemical

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Abstract

Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer-related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis. We review its discovery and development as a cancer chemopreventive agent with the intention of encouraging further research on this important compound and facilitating the identification and development of new phytochemicals for cancer prevention.

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Correspondence to Yuesheng Zhang.

Additional information

Studies carried out in the authors' laboratory were supported in part by US Public Service Grants CA80962 and CA100623.

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Keywords

  • chemoprevention
  • phytochemical
  • isothiocyanate
  • sulforaphane
  • broccoli

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