Abstract
Aim:
To analyze the volatile chemical components of the herbal pair Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra (RLC-RPR) and compare them with those of each of the herbs alone.
Methods:
Gas chromatography-mass spectrometry (GC-MS), a chemometric resolution technique using the heuristic evolving latent projections (HELP) method, and the overall volume integration method were used.
Results:
In total, 52, 38, and 61 volatile chemical components in RLC, RPR, and RLC-RPR essential oils were determined, respectively, accounting for 95.14%, 95.19%, and 89.68% of the total contents of essential oil of RLC, RPR, and RLC-RPR, respectively. The main volatile chemical components were butyldienephthalide (20.65%) and ligustilide (50.15%) for RLC; and n-hexadecanoic acid (20.18%), [Z,Z]9,12-octadecadienoic acid (30.11%), 2-hydroxy-benzaldehyde (17.08%) for RPR, and butyldienephthalide (14.80%), and ligustilide (38.91%) for RLC-RPR. The main volatile chemical components of RLC-RPR were almost the same as those of RLC, but the relative amounts were altered.
Conclusion:
The number of volatile chemical components in RLC-RPR was almost equal to the sum of the number in the 2 constituent herbs, but the relative amounts were altered. Furthermore, an acid-base reaction takes place during the process of decocting the herbs. The data gathered in this study may be helpful for understanding the synergistic nature of this herb pair in traditional Chinese medicine.
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Project supported by the National Natural Science Foundation of China (No 2017503, 20235020) and the Scientific Innovation Project of the Education Ministry of China (No 704036).
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Li, Xr., Lian, Yz. & Guo, Fq. Analysis of volatile oil in Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra by gas chromatography-mass spectrometry and chemometric resolution. Acta Pharmacol Sin 27, 491–498 (2006). https://doi.org/10.1111/j.1745-7254.2006.00305.x
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DOI: https://doi.org/10.1111/j.1745-7254.2006.00305.x
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