Original Contribution | Published:


Editorial: Widening the Use of the Functional Lumen Imaging Probe to Kids With Eosinophilic Esophagitis: Esophageal Narrowing is not Just an Adult Problem

The American Journal of Gastroenterology volume 112, pages 14741476 (2017) | Download Citation


Abstract: The functional lumen imaging probe (FLIP) provides objective measurement of esophageal distensibility, thus offering a unique and potentially valuable assessment in eosinophilic esophagitis (EoE). Menard-Katcher and colleagues report the first study evaluating use of FLIP in pediatric patients that demonstrated a reduction in esophageal distensibility in patients with EoE compared to patients without EoE. An increase in esophageal distensibility was observed with age among pediatric patients without EoE, but not among those with EoE. While this study further supports the promise of esophageal distensibility assessment in EoE, future work remains needed to optimize FLIP utilization in both research and clinical settings.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    , , et al. Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner. Gastroenterology 2013;145:1230–6 e1-2.

  2. 2.

    , , et al. A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease. Gastrointest Endosc 2014;79:577–85 e4.

  3. 3.

    , , et al. Oesophageal narrowing is common and frequently under-appreciated at endoscopy in patients with oesophageal eosinophilia. Aliment Pharmacol Ther 2014;40:1333–1340.

  4. 4.

    , , et al. Mechanical properties of the esophagus in eosinophilic esophagitis. Gastroenterology 2011;140:82–90.

  5. 5.

    , , et al. Esophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2013;11:1101–7 e1.

  6. 6.

    , , et al. Influence of age and eosinophilic esophagitis on esophageal distensibility in a pediatric cohort. Am J Gastroenterol 2017 (this issue).

  7. 7.

    , , et al. A comparison of symptom severity and bolus retention with Chicago classification esophageal pressure topography metrics in patients with achalasia. Clin Gastroenterol Hepatol 2013;11:131–137.

  8. 8.

    , , et al. Severity of endoscopically identified esophageal rings correlates with reduced esophageal distensibility in eosinophilic esophagitis. Endoscopy 2016;48:794–801.

  9. 9.

    , . Clinical implications and pathogenesis of esophageal remodeling in eosinophilic esophagitis. Gastroenterol Clin North Am 2014;43:297–316.

  10. 10.

    , , et al. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol 2007;119:206–212.

  11. 11.

    . Functional lumen imaging probe: the FLIP side of esophageal disease. Curr Opin Gastroenterol 2016;32:310–318.

  12. 12.

    , , et al. Evaluation of esophageal distensibility in eosinophilic esophagitis: an update and comparison of functional lumen imaging probe analytic methods. Neurogastroenterol Motil 2016;28:1844–1853.

  13. 13.

    , , . Mechanical characteristics of distension-evoked peristaltic contractions in the esophagus of systemic sclerosis patients. Dig Dis Sci 2011;56:3559–3568.

  14. 14.

    , , et al. White Paper AGA: Drug Development for Eosinophilic Esophagitis. Clin Gastroenterol Hepatol 2017;15:1173–1183.

Download references

Author information


  1. Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

    • Dustin A Carlson


  1. Search for Dustin A Carlson in:

Competing interests

Guarantor of the article: Dustin A. Carlson, MD, MS.

Specific author contributions: Drafting and final approval of the article: Dustin Carlson

Financial support: None.

Potential competing interests: None.

Corresponding author

Correspondence to Dustin A Carlson.

About this article

Publication history






Further reading