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Editorial

IgG-Mediated Food Intolerance in Irritable Bowel Syndrome: A Real Phenomenon or an Epiphenomenom?

The American Journal of Gastroenterology volume 100, pages 15581559 (2005) | Download Citation

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Abstract

Abnormal reactions to food probably contribute to the complex pathophysiology of irritable bowel syndrome, but the mechanisms involved remain unclear. Following the recent identification of subtle mucosal inflammation in at least some patients with the disorder, perhaps now is the time to revisit some of the immunological reactions to dietary antigens that, in the past, have been dismissed as irrelevant.

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References

  1. 1.

    , . Pain is temporally related to eating but not defaecation in the irritable syndrome (IBS). Patients' description of diarrhea, constipation and symptom variation during 6-week study. Eur J Gastroenterol Hepatol 1998;10: 415–421

  2. 2.

    , , , et al. Sugar malabsorption in functional bowel disease: Clinical implications. Am J Gastroenterol 1993;88(12):2044–2050.

  3. 3.

    , , , et al. Food elimination based on IgG antibodies in irritable bowel syndrome: A randomised controlled trial. Gut 2004;53: 1459–1464

  4. 4.

    . IgG and IgA antibodies to dietary antigens in food allergy and intolerance. Clin Exp Allergy 1995;25 Suppl 1: 7–9.

  5. 5.

    , , . Food hypersensitivity and irritable bowel syndrome. Aliment Pharmacol Ther 2001;15: 439–449.

  6. 6.

    , . Unproved diagnostic and therapeutic approaches to food allergy and intolerance. Curr Opin Allergy Clin Imunol 2003;3: 217–221.

  7. 7.

    , , . Food specific Serum IgG4 and IgE titres to common food antigens in irritable bowel syndrome. Am J Gastroenterol 2005;100: 1550–1557

  8. 8.

    , , . Tregs and allergic disease. J Clin Invest 2004;114: 1389–1397.

  9. 9.

    , , , et al. Oral disodium cromoglycate treatment on irritable bowel syndrome: An open study on 101 subjects with diarrheic type. Am J Gastroenterol 1992;87(1):55–57.

  10. 10.

    , , , et al. Oral cromolyn sodium in comparison with elimination diet in the irritable bowel syndrome, diarrheic type. Multicenter study of 428 patients. Scand J Gastroenterol 1995;30(6):535–541.

  11. 11.

    , , , et al. Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance. Clin Exp Allergy 1991;21(5):569–572.

  12. 12.

    . Infection, immune function and functional gut disorders. Clin Gastroenterol Hepatol. 2004;2: 445–455.

  13. 13.

    , , , et al. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology. 2002;123: 689–699.

  14. 14.

    , , , et al. Colonic bacteria express an ulcerative colitis pANCA-related protein epitope. Infect Immun. 2000;68: 1542–158.

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Author information

Affiliations

  1. Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, , Manchester, UK

    • Fergus Shanahan
  2. Department of Medicine, Education & Research Centre, Wythenshawe Hospital, Manchester, UK

    • Peter J. Whorwell

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Corresponding author

Correspondence to Peter J. Whorwell.

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DOI

https://doi.org/10.1111/j.1572-0241.2005.50009.x