Figure 4

From: Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma

Figure 4

Enhancement of paxlitaxel-induced apoptosis following cannabinoid 2 receptor (CB2) or interleukin (IL)-12 expression. (a) ARO, ARO/vector, ARO/CB2 and ARO/IL-12 cells were treated with 15 nM paclitaxel for 24 h, and stained with annexin V and propidium iodide (PI). Apoptotic cells were quantified by flow cytometry analysis. At least twofold increases in apoptosis were found in ARO/CB2 and ARO/IL-12 cells following 15 nM paclitaxel treatments. The data are expressed as means±s.e.m. of four separate experiments. (b) Representative results of flow cytometry analysis of apoptotic cells. ARO and ARO/IL-12 cells were treated with 15 nM paclitaxel for 24 h, and stained with annexin V and PI. Significant increase in apoptosis was observed in ARO/IL-12 cells following paclitaxel treatment.