Figure 6 | Cancer Gene Therapy

Figure 6

From: Paclitaxel and vincristine potentiate adenoviral oncolysis that is associated with cell cycle and apoptosis modulation, whereas they differentially affect the viral life cycle in non-small-cell lung cancer cells

Figure 6

VCR enhances Ad5-dependent oncolysis and does not affect Ad assembly and release. The effect of VCR on Ad5-dependent oncolysis in H460 cells was examined by MTT assays (a, 2 days; b, 5 days post-infection), RT-PCR analyses of Ad genes expression (c), determination of replication and release indices (d and e, respectively), and analyses of propidium iodide (PI)-stained cells for cell-cycle progression (f, 6 h; g, 24 h) and apoptosis induction (h). The P-value was calculated by comparing the values of apoptotic cells after Ad5 infection or in combination with different concentrations of VCR at a certain time point using Student's t-test.

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