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  • Original Article
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Human exposure to indoor residential cyfluthrin residues during a structured activity program

Abstract

Estimations of absorbed daily dosage (ADD) of chemicals following contact with treated surfaces may be required for risk assessment and risk management. Measurements of ADD based upon biomonitoring are a more reliable data than estimates of ADD from environmental measurements since they require fewer default assumptions. Study participants performed a structured activity program (SAP) 24-h after an application of Tempo® 20 WP (cyfluthrin; 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid cyano(4-fluoro-3-phenoxy-phenyl)-methyl ester) on a medium pile, plush nylon carpet. Measurements of total cyfluthrin residue and transferable cyfluthrin residue (cotton cloth and CDFA roller; personal sock and short dosimetry) were made at 3, 7, 12, 23, 47.5, and 407.5 h. Total cyfluthrin residue extracted from (Soxhlet extraction) carpet was 11.1±2.7 μg/cm2 1 h prior to the SAP. Transferable cyfluthrin residue obtained through analysis of cotton cloths rolled with a weighted 30-pound cylinder was 0.11 μg/cm2. Cyfluthrin residues from socks and shorts were 0.74±0.23 and 0.15±0.03 μg/cm2, respectively. Urine was collected at 12-h intervals during a 72-h period following the SAP and was analyzed for the cyfluthrin biomarker, 4-fluoro-3-phenoxybenzoic acid (FPBA). The mean cyfluthrin equivalents excreted were 8.4±5.7 μg/person (yielding an absorbed dosage of 0.10 μg/kg; n=7). The elimination half-life was 16±5 h. All predicted ADDs based upon environmental measurements overestimated the ADDs measured by urinary excretion.

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References

  • Bernard C., Dinoff T., Nguyen H., Truong D., and Krieger R . Human exposure following indoor insecticide use. Paper Presented at the Annual Meeting of the American Chemical Society, Anaheim, CA, 1999.

  • Bernard C., Nguyen H., Truong D., and Krieger R . Environmental residues and biomonitoring estimates of human insecticide exposure from treated residential turf. Arch Environ Contam Toxicol 2001: 41 (2): 237–240.

    Article  CAS  Google Scholar 

  • Berteau P., Knaak J., Mengle D., and Schreider J . In: Wang, R., Franklin Honeycutt, R., and Reinert, J. (Eds.). Insecticide Absorption from Treated Surfaces. American Chemical Society Symposium Series 382. American Chemical Society, Washington, DC, 1989, pp. 315–326.

    Google Scholar 

  • Hill R., Head S., Baker S., Gregg M., Shealy D., Bailey S., Williams C., Sampson E., and Needham L . Pesticide residues in urine of adults living in the United States: Reference range concentrations. Environ Res 1995: 17: 99–108.

    Article  Google Scholar 

  • Iwata Y., Knaak J., Spear R., and Foster R . Worker reentry into pesticide-treated crops. I. Procedure for the determination of dislodgeable pesticide residues on foliage. Bull Environ Contam Toxicol 1977: 18: 1–6.

    Article  Google Scholar 

  • Krieger R. In: Curry P., Iyengar S., Maloney P., and Maroni M. (Eds.), Methods of Pesticide Exposure Assessment. Plenum Press, New York, 1995, pp. 129–132.

    Book  Google Scholar 

  • Krieger R. In: Ragsdale N., and Seiber J. (Eds.), Pesticides: Managing Risks and Optimizing Benefits. American Chemical Society Symposium Series 734. American Chemical Society, Washington, DC, 1999, pp. 117–132.

    Chapter  Google Scholar 

  • Krieger R., Bernard C., Dinoff T., Dowling K., Fell L., Nguyen H., Osimitz T., Ross J., and Thongsinthusak T . Experimental and situational exposure monitoring of human exposure to household insecticide use. Abstr Papers Am Chem Soc 1997: 214.

  • Krieger R., Bernard C., Dinoff T., Fell L., Osimitz T., Ross J., and Thongsinthusak T . Biomonitoring and whole body cotton dosimetry to estimate potential human dermal exposure to semivolatile chemicals. J Expo Anal Environ Epidemiol 2000: 10: 50–57.

    Article  CAS  Google Scholar 

  • Krieger R., Bernard C., Dinoff T., Ross J., and Williams R . Biomonitoring of persons exposed to insecticides used in residences. Ann Occup Hyg 2001: 45: S143–S153.

    Article  CAS  Google Scholar 

  • Kuhn K., Leng G., Bucholski K., Dunemann L., and Idel H. Determination of pyrethroid metabolites in human urine by capillary gas chromatography–mass spectrometry. Chromatographia 1996: 43: 285–292.

    Article  Google Scholar 

  • Leng G., Kuhn K., and Idel H . Biological monitoring of pyrethroids in blood and pyrethroid metabolites in urine: applications and limitations. Sci Total Environ 1997: 199: 173–181.

    Article  CAS  Google Scholar 

  • Ross J., Fong H., Thongsinthusak T., Margetich S., and Krieger R . Measuring potential dermal transfer of surface pesticide residue generated from indoor fogger use: using the CDFA roller method interim report II. Chemosphere 1991: 22: 975–984.

    Article  CAS  Google Scholar 

  • Ross J., Thongsinthusak T., Fong H., Margetich S., and Krieger R . Measuring potential dermal transfer of surface pesticide residue generated from indoor fogger use: an interim report. Chemosphere 1990: 20: 349–360.

    Article  CAS  Google Scholar 

  • Rowland M., and Tozer T . Appendix C. Estimation of the elimination half-life from cumulative urine data. In: Clinical Pharmacokinetics: Concepts and Applications. Lea and Febiger, Philadelphia, PA, 1980, pp. 291–293.

    Google Scholar 

  • Rust M. Factors affecting control with residual insecticide deposits. In: Rust M., Owens J., and Reierson D. (Eds.). Understanding and Controlling the German Cockroach. Oxford University Press, New York, 1995, pp. 149–170.

    Google Scholar 

  • Thongsinthusak T., Ross J., and Meinders D . Guidance for the preparation of human pesticide exposure assessment documents (HS-1612). Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA, 1993.

  • USEPA. Exposure Factors Handbook Vol. 1. EPA/600/P-95/002FA. USEPA Office of Research and Development. 1997a.

  • USEPA. Standard Operating Procedures (SOPs) for residential Q7exposure assessments. Available at: www.epa.gov/oscpmont/sap/1997/september/1sess.htm. USEPA Office of Science Coordination and Policy 1997b.

  • Williams R., Bernard C., and Krieger R . Influence of moisture on pesticide residue availability following indoor applications. Paper presented at the Annual Meeting of the American Chemical Society, San Francisco, CA, 2000.

  • Woollen B., Marsh J., Laird W., and Lesser J . The metabolism of cypermethrin in man: differences in urinary metabolite profiles following oral and dermal administration. Xenobiotica 1992: 22: 983–991.

    Article  CAS  Google Scholar 

  • Zartarian V., Ferguson A., and Leckie J . Quantified dermal activity data from a four-child pilot field study. J Clean Technol Environ Toxicol Occup Med 1998: 7 (3): 259–268.

    Google Scholar 

  • Zweig G., Leffingwell J., and Popendorf W . The relationship between dermal pesticide exposure by fruit harvesters and dislodgeable foliar residues. J Environ Sci Health 1985: 20: 27–59.

    Article  CAS  Google Scholar 

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Acknowledgements

The authors are grateful to the study participants for their time, cooperation, and commitment to the requirements of this study. Kelly Tyson provided experience, direction, and enthusiasm as instructor for the Jazzercise® activity. Anasthasia Krieger is thanked for her general assistance with all aspects of the SAP. Various donors including S. C. Johnson and Bayer Corporation, Agriculture Division, have provided unrestricted grants-in-aid.

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Correspondence to Robert I Krieger.

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Williams, R., Bernard, C. & Krieger, R. Human exposure to indoor residential cyfluthrin residues during a structured activity program. J Expo Sci Environ Epidemiol 13, 112–119 (2003). https://doi.org/10.1038/sj.jea.7500257

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