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Maternal bisphenol-A levels at delivery: a looming problem?

Journal of Perinatology volume 28, pages 258–263 (2008)Cite this article

Abstract

Objective:

The objective was to determine whether bisphenol-A (BPA) is found in maternal circulation of pregnant women in the US population and is related to gestational length and birth weight.

Method:

Circulating levels of BPA were quantified by high performance liquid chromatography-tandem mass spectrometry at delivery in 40 southeastern Michigan mothers and correlated with gestational length and birth weight of offspring.

Result:

Maternal levels of unconjugated BPA ranged between 0.5 and 22.3 ng ml−1 in southeastern Michigan mothers. There was no correlation between BPA concentrations and gestational length or birth weight of offspring.

Conclusion:

This is the first study to document measurable levels of BPA in maternal blood of the US population. Long-term follow-up studies of offspring are needed to validate or refute concerns over human fetal exposure to synthetic exogenous steroids.

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Acknowledgements

We thank Dr Mohan Manikkam and Mr James S Lee for assistance with the processing of human blood samples and procurement of sheep blood samples, respectively. This study was supported by P20RR020682 from the National Institutes of Health.

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Authors and Affiliations

  1. Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA

    V Padmanabhan

  2. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA

    V Padmanabhan, T Johnson, J Pinkerton & L Anderson

  3. School of Social Work, University of Michigan, Ann Arbor, MI, USA

    K Siefert

  4. University of North Texas Health Science Center, Fort Worth, TX, USA

    S Ransom

  5. New York State Department of Health and Department of Environmental Health Sciences, Wadsworth Center, School of Public Health, State University of New York, Empire State Plaza, Albany, NY, USA

    L Tao & K Kannan

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  1. V Padmanabhan
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Correspondence to V Padmanabhan.

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Padmanabhan, V., Siefert, K., Ransom, S. et al. Maternal bisphenol-A levels at delivery: a looming problem?. J Perinatol 28, 258–263 (2008). https://doi.org/10.1038/sj.jp.7211913

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  • DOI: https://doi.org/10.1038/sj.jp.7211913

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