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Amnioinfusion in preterm PROM: effects on amnion and cord histology

Journal of Perinatology volume 28, pages 97–101 (2008)Cite this article

Abstract

Objective:

To investigate the effects of transabdominal amnioinfusion (TA) on the histology of amnion (A) and umbilical cord (UC).

Study Design:

From a cohort of 56 singleton pregnancies with premature rupture of membranes (PROM) at ⩽24.6 weeks, we excluded those who did not develop severe oligohydramnios (n=12). Of the 44 patients, 29 consented to TA and 15 declined the procedure. TA was performed with normal saline solution.

Result:

Women who consented to TA underwent a median of three procedures had a gestational age at PROM of 18.7 weeks and at delivery of 26.1 weeks, with a latency of 50 days. Compared with subjects who declined the procedure, TA had a beneficial effect on clinical variables, mediated primarily by a longer latency. TA was not associated with identifiable effects on the histologic features of A or UC.

Conclusion:

A and UC histology is not significantly affected by exposure to saline solution even for prolonged periods of time.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy

    A Locatelli, M Andreani, A Ghidini, M Verderio, A Pizzardi & P Vergani

  2. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

    C M Salafia

Authors
  1. A Locatelli
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  2. M Andreani
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  3. A Ghidini
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  4. M Verderio
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  5. A Pizzardi
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  6. P Vergani
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  7. C M Salafia
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Corresponding author

Correspondence to A Locatelli.

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Locatelli, A., Andreani, M., Ghidini, A. et al. Amnioinfusion in preterm PROM: effects on amnion and cord histology. J Perinatol 28, 97–101 (2008). https://doi.org/10.1038/sj.jp.7211876

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  • DOI: https://doi.org/10.1038/sj.jp.7211876

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