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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Currarino syndrome as an etiology of a neonatal Escherichia coli meningitis

Journal of Perinatology volume 27, pages 589–591 (2007)Cite this article

Abstract

We report the case of a 29-day-old baby girl in whom Escherichia coli meningitis led to the diagnosis of Currarino syndrome (CS) (OMIM 176450), an autosomal-dominant genetic disorder associated with sacral agenesis, anorectal malformation, presacral masses and spinal cord malformations. Her condition improved with antibiotics and early surgical treatment. A familial study identified other genetically related individuals with similar symptoms.

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References

  1. Guerin JM, Leibinger F, Raskine L, Ekherian JM . Polymicrobial meningitis revealing an anterior sacral meningocele in a 23-year-old woman. J Infect 2000; 40: 195–197.

    Article  CAS  Google Scholar 

  2. Currarino G, Coln D, Votteler T . Triad of anorectal, sacral, and presacral anomalies. Am J Roentgenol 1981; 137: 395–398.

    Article  CAS  Google Scholar 

  3. Ross AJ, Ruiz-Perez V, Wang Y, Hagan DM, Scherer S, Lynch SA et al. A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. Nat Genet 1998; 20: 358–361.

    Article  CAS  Google Scholar 

  4. Hagan DM, Ross AJ, Strachan T, Lynch SA, Ruiz-Perez V, Wang YM et al. Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene. Am J Hum Genet 2000; 66: 1504–1515.

    Article  CAS  Google Scholar 

  5. Belloni E, Martucciello G, Verderio D, Ponti E, Seri M, Jasonni V et al. Involvement of the HLXB9 Homeobox gene in Currarino syndrome. Am J Hum Genet 2000; 66: 312–319.

    Article  CAS  Google Scholar 

  6. Gegg CA, Vollmer DG, Tullous MW, Kagan-Hallet KS . An unusual case of the complete Currarino triad: case report, discussion of the literature and the embryogenic implications. Neurosurgery 1999; 44: 658–662.

    Article  CAS  Google Scholar 

  7. Garcia-Barcelo M, So MT, Lau DK, Leon TY, Yuan ZW, Cai WS et al. Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome. Clin Chem 2006; 52: 46–52.

    Article  CAS  Google Scholar 

  8. Lynch SA, Wang Y, Strachan T, Burn J, Lindsay S . Autosomal dominant sacral agenesis: Currarino syndrome. J Med Genet 2000; 37: 561–566.

    Article  CAS  Google Scholar 

  9. Kochling J, Karbasiyan M, Reis A . Spectrum of mutations and genotype-phenotype analysis in Currarino syndrome. Eur J Hum Genet 2001; 9: 599–605.

    Article  CAS  Google Scholar 

  10. Cretolle C, Zerah M, Jaubert F, Sarnacki S, Revillon Y, Lyonnet S et al. New clinical and therapeutic perspectives in Currarino syndrome. J Pediatr Surg 2006; 41: 126–131.

    Article  Google Scholar 

  11. Samuel M, Hosie G, Holmes K . Currarino triad—diagnostic dilemma and a combined surgical approach. J Pediatr Surg 2000; 35: 1790–1794.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Clinique Médicale Pédiatrique, Hôpital Mère Enfant CHU Nantes, CHU Nantes, France

    J Fleury & G Picherot

  2. Service de Chirurgie Viscérale Infantile et INSERM U781, Hôpital Necker-Enfants Malades, Paris, France

    C Cretolle

  3. Service de Chirurgie Infantile, Hôpital Mère Enfant CHU Nantes, CHU Nantes, France

    G Podevin

  4. Service de Génétique Médicale, CHU Nantes, France

    A David

  5. Laboratoire de Microbiologie, CHU Nantes, France

    J Caillon

  6. UPRES EA 3826, Faculté de Médecine de Nantes, Nantes, France

    J Caillon & C Gras-le Guen

  7. Service de Néonatologie, Hôpital Mère Enfant CHU Nantes, CHU Nantes, France

    J C Roze & C Gras-le Guen

Authors
  1. J Fleury
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  2. G Picherot
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  3. C Cretolle
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  4. G Podevin
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  5. A David
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  6. J Caillon
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  7. J C Roze
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  8. C Gras-le Guen
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Corresponding author

Correspondence to C Gras-le Guen.

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Fleury, J., Picherot, G., Cretolle, C. et al. Currarino syndrome as an etiology of a neonatal Escherichia coli meningitis. J Perinatol 27, 589–591 (2007). https://doi.org/10.1038/sj.jp.7211783

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  • DOI: https://doi.org/10.1038/sj.jp.7211783

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