Abstract
Objective:
To determine if a change in the pulse oximeter goal range and high alarm limit for oxygen saturation (SpO2) alters the distribution of SpO2 for premature infants in oxygen.
Study design:
This was a prospective, observational analysis. For group 1 (February 2002 to April 2002, n=23), pulse oximeter alarms were set at 80% (low) and 96% (high), and the goal range was 90–95%. For group 2 (May 2002 to August 2003, n=49), the high alarm was lowered to 94%, and the goal range was 88 to 94%. The SpO2 values for 24 h were downloaded from Nellcor pulse oximeters during the two periods and the percent time within, above and below the goal range was derived and compared.
Results:
Groups were similar except for use of post-natal steroids (group 2>1). The percent time within (57.7±9.8 vs 59.4±12.4%), above (15.4±10.6 vs 14±9.4%) and below (26.9±9.7 vs 26.6±10.2%) the goal range was similar for groups 1 and 2, respectively. However, the percent time with SpO2 <80% increased significantly for group 2 (4.0±2.7 vs 1.9±1.4%).
Conclusions:
Changes in pulse oximeter policy and alarms in labile, sick premature infants need evaluation for their effects on the distribution of SpO2 values before routine use.
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References
Jobe AH . The new BPD: an arrest of lung development. Pediatr Res 1999; 46: 641–643.
Jobe AH, Ikegami M . Mechanisms initiating lung injury in the preterm. Early Hum Develop 1998; 53: 81–94.
Kinsy VE . Retrolental fibroplasias. Cooperative study of retrolental fibroplasia and the use of oxygen. AMA Arch Ophthalmol 1956; 56: 481–543.
Flynn JT, Bancalari E, Snyder ES, Goldberg RN, Feuer W, Cassady J et al. A cohort study of transcutaneous oxygen tension and the incidence and severity of retinopathy of prematurity. N Engl J Med 1992; 326: 1050–1054.
Hay WW, Brockway JM, Eyzaguirre M . Neonatal pulse oximetry: accuracy and reliability. Pediatrics 1989; 83: 717–722.
Jennis MS, Peabody JL . Pulse oximetry: an alternative method for the assessment of oxygenation in newborn infants. Pediatrics 1987; 79: 524–528.
Paky F, Koeck CM . Pulse oximetry in ventilated preterm newborns: reliability of detection of hypoxaemia, and feasibility of alarm settings. Acta Paediatr 1995; 84: 6132–6616.
Wasunna A, Whitelaw AGL . Pulse oximetry in preterm infants. Arch Dis Child 1987; 62: 957–961.
Wilkinson AR, Phibbs RH, Heilbron DC, Gregory GA, Versmold HT . In vivo dissociation curves in transfused and untransfused newborns with cardiopulmonary disease. Am Rev Resp Dis 1980; 122: 629–634.
Saugstad OD . Is oxygen more toxic than currently believed? Pediatrics 2001; 108: 1203–1205.
Cole CH, Wright KW, Tarnow-Mordi W, Phelps DL . Resolving our uncertainty about oxygen therapy. Pediatrics 2003; 112: 1415–1419.
Claure N, Gerhardt T, Everett R, Musante G, Herrera C, Bancalari E . Closed-loop controlled inspired oxygen concentration for mechanically ventilated very low birth weight infants with frequent episodes of hypoxemia. Pediatrics 2001; 107: 1120–1124.
Hay WW, Rodeen DJ, Collins SM, Melara DL, Hale KA, Fashaw LM . Reliability of conventional and new pulse oximetry in neonatal patients. J Perinatol 2002; 22: 360–366.
Grieve SH, McIntosh N, Laing IA . Comparison of two different pulse oximeters in monitoring preterm infants. Crit Care Med 1997; 25: 2051–2054.
STOP-ROP Multicenter study group. Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity (STOP-ROP), a randomized controlled trial. I: Primary outcomes. Pediatrics 2000; 105: 295–310.
Askie LM, Henderson-Smart DJ, Irwig L, Simpson JM . Oxygen-saturation targets and outcomes in extremely preterm infants. N Engl J Med 2003; 349: 959–967.
Tin W, Milligan DW, Pennefather P, Hey E . Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation. Arch Dis Child Fetal Neonatal Ed 2001; 84: F106–F110.
Chow LC, Wright KW, Sola S . Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants? Pediatrics 2003; 111: 339–345.
Vijayakumar E, Ward GJ, Bullock CE, Patterson ML . Pulse oximetry in infants of <1500 g birth weight on supplemental oxygen: a national survey. J Perinatol 1997; 17: 341–345.
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Laptook, A., Salhab, W., Allen, J. et al. Pulse oximetry in very low birth weight infants: can oxygen saturation be maintained in the desired range?. J Perinatol 26, 337–341 (2006). https://doi.org/10.1038/sj.jp.7211500
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DOI: https://doi.org/10.1038/sj.jp.7211500
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