Table 2 Diagnostic accuracies of LBP, IL-8 and CRP within 6, 12 and 24 h after the first suspicion of early-onset bacterial infection

From: Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection

6 h LBP>6.0 μg/ml IL-8>60pg/ml CRP>10mg/l
Sensitivity % 45 (24–68) 68 (55–89) 9 (1–28)
Specificity % 82 (69–91) 82 (69–91) 98 (90–100)
Pos. pred. value % 15 (3–38) 20 (6–46) 3 (0–25)
Neg. pred. value % 54 (39–68) 74 (49–88) 65 (50–77)
12 h LBP>9 μg/ml IL-8>60pg/ml CRP>10mg/l
Sensitivity % 79 (54–94) 58 (28–77) 39 (19–64)
Specificity % 76 (63–87) 78 (62–89) 96 (85–99)
Pos. pred. value % 27 (9–49) 17 (3–38) 13 (2–33)
Neg. pred. value % 50 (36–64) 51 (36–65) 63 (47–75)
24h LBP>15 μg/ml IL-8>60pg/ml CRP>10mg/l
Sensitivity % 77 (56–91) 23 (9–79)) 96 (81–100)
Specificity % 67 (53–80) 77 (63–87) 81 (65–89)
Pos. pred. value % 26 (11–46) 8 (1–25) 32 (16–56)
  1. (): exact 95% confidence interval based on the binomial sampling process.