Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Neonatal/Perinatal Case Presentation
  • Published:

Neonatal/Perinatal Case Presentation

Persistent Perianal Abscess in Early Infancy as a Presentation of Autoimmune Neutropenia

Journal of Perinatology volume 23, pages 428–430 (2003)Cite this article

Abstract

Autoimmune neutropenia of infancy is a primary, usually self-limiting, antineutrophil autoimmune phenomenon seen in infancy and early childhood. These infants are at a higher risk of infection, and early detection, particularly with the availability of newer therapeutic options such as hematopoietic growth factors, can allow close follow-up and, if needed, treatment. We report two infants with autoimmune neutropenia who presented with a persistent perianal abscess, which has not been documented previously in this population.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bux J, Behrens G, Jaeger G, Welte K . Diagnosis and clinical course of autoimmune neutropenia in infancy: analysis of 240 cases. Blood 1998;91:181–186.

    CAS  PubMed  Google Scholar 

  2. Taniuchi S, Masuda M, Yamamoto A, et al. Two cases of autoimmune neutropenia possibly induced by beta-lactam antibiotics in infants. J Pediatr Hematol Oncol 2000;22:533–538.

    Article  CAS  Google Scholar 

  3. Murray JC, Morad AB . Childhood autoimmune neutropenia and human parvovirus B19. Am J Hematol 1994;47:336.

    Article  CAS  Google Scholar 

  4. Dale DC . Immune and idiopathic neutropenia. Curr Opin Hematol 1998;5:33–36.

    Article  CAS  Google Scholar 

  5. Bux J, Mueller-Eckhardt G, Mueller-Eckhardt C . Autoimmunization against the neutrophil-specific NA1 antigen is associated with HLA-DR2. Hum Immunol 1991;30:18–21.

    Article  CAS  Google Scholar 

  6. Taniuchi S, Masuda M, Yamamoto A, et al. FcgammaRIII b and FcgammaRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy. Hum Immunol 2001;62:408–413.

    Article  CAS  Google Scholar 

  7. Conway LT, Clay ME, Kline WE, Ramsay NK, Krivit W, McCullough J . Natural history of primary autoimmune neutropenia in infancy. Pediatrics 1987;79:728–733.

    CAS  PubMed  Google Scholar 

  8. Bruin MC, von dem Borne AE, Tamminga RY, Kleijer M, Buddelmeijer L, de Haas M . Neutrophil antibody specificity in different types of childhood autoimmune neutropenia. Blood 1999;94:1797–1802.

    CAS  PubMed  Google Scholar 

  9. Shastri KA, Logue GL . Autoimmune neutropenia. Blood 1993;81:1984–1995.

    CAS  PubMed  Google Scholar 

  10. Calhoun DA, Rimsza LM, Burchfield DJ, et al. Congenital autoimmune neutropenia in two premature neonates. Pediatrics 2001;108:181–184.

    Article  CAS  Google Scholar 

  11. Kummerle-Deschner J, Scheel-Walter HG, Speer CP . G-CSF therapy in a neonate with alloimmune neutropenia. Z Geburtshilfe Neonatol 1997;201:273–276.

    CAS  PubMed  Google Scholar 

  12. North Jr JH, Weber TK, Rodriguez-Bigas MA, Meropol NJ, Petrelli NJ . The management of infectious and noninfectious anorectal complications in patients with leukemia. J Am Coll Surg 1996;183:322–328.

    PubMed  Google Scholar 

  13. Welte K, Dale D . Pathophysiology and treatment of severe chronic neutropenia. Ann Hematol 1996;72:158–165.

    Article  CAS  Google Scholar 

  14. Uguz A, Yilmaz E, Ciftcioglu MA, Yegin O . An unusual presentation of immunodeficiency with hyper-IgM. Pediatr Dermatol 2001;18:48–50.

    Article  CAS  Google Scholar 

  15. Ventura A, Dragovich D, Luxardo P, Zanazzo G . Human granulocyte colony-stimulating factor (rHuG-CSF) for treatment of neutropenia in Shwachman syndrome. Haematologica 1995;80:227–229.

    CAS  PubMed  Google Scholar 

  16. Visser G, Rake JP, Fernandes J, et al. Neutropenia, neutrophil dysfunction, and inflammatory bowel disease in glycogen storage disease type Ib: results of the European Study on Glycogen Storage Disease type I. J Pediatr 2000;137:187–191.

    Article  CAS  Google Scholar 

  17. Watanabe Y, Todani T, Yamamoto S . Conservative management of fistula in ano in infants. Pediatr Surg Int 1998;13:274–276.

    Article  CAS  Google Scholar 

  18. Carulli G . Treatment of autoimmune neutropenia with recombinant human granulocyte colony-stimulating factor. Ann Hematol 1998;76:93–94.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by Grants HD-01180 and HD-42326 (Dr. Calhoun) and HL-61798 (Dr. Christensen) from the National Institutes of Health.

Author information

Authors and Affiliations

  1. Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of South Florida College of Medicine and All Children's Hospital, St. Petersburg, FL, USA

    Akhil Maheshwari MD, Darlene A Calhoun DO & Robert D Christensen MD

  2. Department of Pediatrics, Divison of General Academic Pediatrics & Adolescent Medicine, University of South Florida College of Medicine and All Children's Hospital, St. Petersburg, FL, USA

    Marisa Lejkowski DO & Sharon Dabrow MD

  3. Division of Immunology, Department of Pediatrics, University of Florida, Gainesville, FL, USA

    Suzanne Skoda-Smith MD

Authors
  1. Marisa Lejkowski DO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Akhil Maheshwari MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Darlene A Calhoun DO
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robert D Christensen MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Suzanne Skoda-Smith MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sharon Dabrow MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lejkowski, M., Maheshwari, A., Calhoun, D. et al. Persistent Perianal Abscess in Early Infancy as a Presentation of Autoimmune Neutropenia. J Perinatol 23, 428–430 (2003). https://doi.org/10.1038/sj.jp.7210952

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7210952

This article is cited by

Search

Advanced search

Quick links