Stridor in a neonate evokes a series of prompt evaluations to determine the etiology. Common etiologies include inherent structural defects (such as laryngomalacia), vocal fold paralysis, acquired infectious etiologies, or extrinsic compressions. We report a neonate with a lymphatic malformation (lymphangioma) initially confined to the larynx that presented with stridor and progressive respiratory failure. Only seven other cases have been reported to present with lymphatic malformation confined solely to the larynx. There are several different modalities available to treat this condition, but recurrences are common. The presentation and management are discussed below. Physicians should be aware that stridor in a neonate can result from this unusual intrinsic obstruction of the larynx.
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Mancuso RF . Stridor in neonates. Pediatric Clin N Am 1996;43:1339–1356.
Schloss MD, Sweet RC, Blais C, et al. Lymphangioma in children. J Otolaryngol 1984;13:95–98.
Sabin FR . On the origin of the lymphatic system from the veins and the development of lymph, heart and thoracic duct in the pig. Am J Anat 1901;1:367–389.
McClure CFW, Silvester CF . A comparative study of the lymphatic-venous communications in adult mammals. Anat Rec 1909;3:534–553.
Phillips HE, McGahan JP . Intrauterine fetal cystic hygroma: sonographic detection. Am J Roentgenol 1981;136:799–802.
Lee K-J, Klein TR . Surgery of cysts and tumors of the neck. In: Paparella MM, Shumrick DA, editors. Otolaryngology. 2nd ed. Philadelphia, PA: WB Saunders; 1980. pp. 2987–2989.
Eggston AA, Wolf D . Histopathology of the Ear, Nose and Throat. Baltimore, MD: Williams and Wilkins Co; 1947. pp. 770–774.
Handler SD, Raney Jr. BB . Management of neoplasms of the head and neck in children. Head Neck Surg 1981;3:395–405.
Zadvinskis DP, Benson MT, Kerr HH, et al. Congenital malformations of thecervicothoracic lymphatic system: embryology and pathogenesis. Radiographics 1992;12:1175–1189.
Coffin CM, Dehener LP . Vascular Tumors in Children and Adolescents: aclinicopathologic study of 228 tumors in 222 patients. Pathology Annual 1993;28:97–120.
Alqahtani A, Nguyen LT, Flageole H, Shaw K, Laberge JM . 25 years experience with lymphangiomas in children. J Pediatr Surg 1999;34:1164–1168.
Orvidas L, Kasperbauer J . Pediatric lymphangiomas of the head and neck. Ann Otol, Rhinol Laryngol 2000;109:411–421.
Cohen SR, Thompson JW . Lymphangiomas of the larynx in infants and children. A survey of pediatric lymphangioma. Ann Otol, Rhinol, and Laryngol — Supplement 1986;127:1–20.
Papsin BC, Evans G . Isolated laryngeal lymphangioma: a rare cause of airway obstruction in infants. J Laryngol Otol 1996;110:969–972.
Sobol SE, Manoukian JJ . Acute airway obstruction from a laryngeal lymphangioma in a child. Int J Otolaryngol 2001;58:255–257.
Holinger PH, Johnston KC . Benign tumors of the larynx. Ann Otol, Rhinol, and Laryngol 1951;60:496–509.
Selz PA, Arjmand EM . Laryngeal lymphangioma: a case report of an uncommon entity. Otolaryngol — Head Neck Surg 1998;118:382.
Ruben RJ, Kucinski SA, Greenstein N . Cystic lymphangioma of the vallecula. Can J Otolaryngol 1974;4:180–184.
Carlos P, Viscasillas S, Carlos A, Carlos Jr. A . Lymphangioma of the larynx as a cause of progressive dyspnea. Int J Pediatr Otolaryngol 1985;9:263–268.
Williams WT, Cole RR . Lymphangioma presenting as congenital stridor. Int J Pediatr Otolaryngol 1993;26:185–191.
Hartl D, Roger G, Denoyelle F, et al. Extensive lymphangioma presenting with upper airway obstruction. Arch Otolaryngol Head Neck Surg 2000;126:1378–1382.
Raveh E, De Jong AL, Taylor G, et al. Prognostic factors in the treatment of lymphatic malformations. Arch Otolaryngol, Head Neck Surg 1997;123:1061–1065.
White B, Adkins WY . Use of the carbon dioxide laser in head and neck lymphangioma. Lasers Surg Med 1986;6:293–295.
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Kenton, A., Duncan, N., Bhakta, K. et al. Laryngeal Lymphatic Malformation in a Newborn. J Perinatol 23, 567–571 (2003). https://doi.org/10.1038/sj.jp.7210942
Indian Journal of Otolaryngology and Head & Neck Surgery (2011)