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Tolerance of a Sterile Isotonic Electrolyte Solution Containing Select Recombinant Growth Factors in Neonates Recovering From Necrotizing Enterocolitis

Journal of Perinatology volume 23, pages 200–204 (2003)Cite this article

Abstract

OBJECTIVE: To assess the tolerance of a sterile isotonic electrolyte solution containing select recombinant growth factors enterally administered in neonates who were NPO because of necrotizing enterocolitis (NEC).

STUDY DESIGN: A phase I trial was accomplished among 30 neonates. Patients received 5, 10, or 20 mL enterally of the study solution/kg/day divided into every 3-hour dosing, for 3 days prior to when feedings of milk were to resume. The occurrence of emesis, gastric residuals, diarrhea, bloody stools, abdominal distention, skin rashes and death were sought.

RESULTS: Gestational ages ranged from 25.2 to 41.1 weeks. A total of 16 neonates had Stage IA NEC, six Stage IB, and eight Stage IIA. The solution was well tolerated in all 30; none developed diarrhea, guaiac positive or bloody stools, or abdominal distention. Administration of the solution was not prematurely discontinued in any infant. Two neonates died secondary to late-onset sepsis remote from the study period.

CONCLUSIONS: Enteral administration of a sterile isotonic electrolyte solution containing select recombinant growth factors was well tolerated by neonates with NEC.

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Authors and Affiliations

  1. Division of Neonatology, Hospital General Dr. Ignacio Morones Prieto, San Luis Potosi City, San Luis Potosi, Mexico

    Victoria Lima-Rogel MD, Abraham Torres-Montes MD & Raul Roque-Sanchez MD

  2. Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine and All Children's Hospital, St. Petersburg, 33701, FL, USA

    Darlene A Calhoun DO, Akhil Maheshwari MD & Robert D Christensen MD

  3. The National Institute of Perinatology, Mexico City, Mexico

    Maria G Garcia MD

Authors
  1. Victoria Lima-Rogel MD
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  2. Darlene A Calhoun DO
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  3. Akhil Maheshwari MD
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  4. Abraham Torres-Montes MD
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  5. Raul Roque-Sanchez MD
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  6. Maria G Garcia MD
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  7. Robert D Christensen MD
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Supported in part by grants HD-42326 (DAC), HD-01180 (DAC), and HL-61798 (RDC) from the National Institutes of Health.

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Lima-Rogel, V., Calhoun, D., Maheshwari, A. et al. Tolerance of a Sterile Isotonic Electrolyte Solution Containing Select Recombinant Growth Factors in Neonates Recovering From Necrotizing Enterocolitis. J Perinatol 23, 200–204 (2003). https://doi.org/10.1038/sj.jp.7210894

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