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Early and Late Postnatal Identification of Isolated Lenticulostriate Vasculopathy in Preterm Infants: Associated Findings

Journal of Perinatology volume 23, pages 20–23 (2003)Cite this article

Abstract

OBJECTIVES: To determine the incidence, possible etiologies, and neurodevelopmental outcome of premature infants (<35 weeks) with isolated lenticulostriate vasculopathy (LSV).

STUDY DESIGN: In a retrospective case-control design, we reviewed the medical records of all premature infants who were admitted to our neonatal intensive care unit between 1996 and 2000.

RESULTS: The prevalence of LSV was 4.6% (21 of 453). Patients with late LSV (detected after 10 days of age) had less exposure than controls to prenatal steroids [42.8% (6 of 14) vs. 92.8% (13 of 14), respectively; p<0.01], and prenatal antibiotics [42.8% (6 of 14) vs. 85.7% (12 of 14), respectively; p=0.01]. Fifty-seven percent (8 of 14) of patients with late LSV had a low Apgar score vs. 14.2% (2 of 14) of the control group (p=0.01). Patients with LSV also had more muscle tone abnormalities than controls at 6 months of age [33.3% (5 of 15) vs. 5.2% (1 of 19), respectively; p=0.03].

CONCLUSION: Patients with late LSV have less exposure to antenatal steroids and antibiotics, lower Apgar scores, and abnormal muscle tone at 6 months of age.

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Authors and Affiliations

  1. Department of Pediatrics, The Cleveland Clinic Children's Hospital, Cleveland, OH, USA

    A H Hemachandra MD, MPH

  2. Department of Radiology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA

    D Oravec MD

  3. Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA

    M Collin MD, N Tafari MD & Maroun J Mhanna MD

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  1. A H Hemachandra MD, MPH
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  2. D Oravec MD
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  3. M Collin MD
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  5. Maroun J Mhanna MD
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Hemachandra, A., Oravec, D., Collin, M. et al. Early and Late Postnatal Identification of Isolated Lenticulostriate Vasculopathy in Preterm Infants: Associated Findings. J Perinatol 23, 20–23 (2003). https://doi.org/10.1038/sj.jp.7210861

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