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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Fibrin Glue for Persistent Pneumothorax in Neonates

Journal of Perinatology volume 23, pages 82–84 (2003)Cite this article

Abstract

Fibrin glue was used to treat significant pneumothoraces persisting for an average of 10 days in eight newborns. Six of the eight infants had reduction or resolution of persistent air leak within 24 hours of therapy. Two infants received a second course of therapy for recurrences. Complications encountered were bradycardia requiring manual ventilation (N=2), significant hypercalcemia (N=2), diaphragmatic paralysis (N=2), pneumothorax (PTX) on the contralateral side (N=1), and localized tissue necrosis (N=1). Fibrin glue is an effective treatment for intractable PTX but has significant risks.

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References

  1. Gibble JW, Ness PM . Fibrin glue: the perfect operative sealant?. Transfusion 1990; 30: 741–7.

    Article  CAS  Google Scholar 

  2. Lerner R, Bimur NS . Current research review: current status of surgical adhesives. J Surg Res 1990; 48: 165–81.

    Article  CAS  Google Scholar 

  3. Pisciotto PT, Anderson KC, Goodnough LT, Silberstein LE . Current trends: evolving concepts in transfusion medicine: the need for standardization of cryoprecipitate-derived fibrin adhesive. Transfus Sci 1993; 14: 291–4.

    Article  CAS  Google Scholar 

  4. Moront MG, Katz NM, Hoy GR . The use of topical fibrin glue at cannulation sites in neonates. Surg Gynecol Obstet 1988; 166: 358–9.

    CAS  PubMed  Google Scholar 

  5. Nguyen D, Tchervenkov CI . Successful management of postoperative chylothorax with fibrin glue in a premature neonate. Can J Surg 1994; 37: 158–60.

    CAS  PubMed  Google Scholar 

  6. Kuint J, Lubin D, Linder N . Fibrin glue treatment for recurrent pneumothorax in a premature infant. Am J Perinatol 1996; 13: 245–7.

    Article  CAS  Google Scholar 

  7. Berger JT, Gilhooly J . Fibrin glue treatment of persistent pneumothorax in infant. J Pediatr 1993; 122: 958–60.

    Article  CAS  Google Scholar 

  8. Bhatia J, Matthew OP . Resolution of pneumothorax in neonates. Crit Care Med 1985; 13: 417–9.

    Article  CAS  Google Scholar 

  9. Matthew OP, Bhatia J . Management of persistent pneumothorax: an innovative approach. J Pediatr 1983; 103(1): 117–9.

    Article  Google Scholar 

  10. Odita C, Khan ASSI, Ammari A . Neonatal phrenic nerve paralysis resulting from intercostal drainage of pneumothorax. Pediatr Radiol 1992; 22: 379–81.

    Article  CAS  Google Scholar 

  11. Goldman CD, Blocker SH, Ternberg JL, Crouch EC . Management of experimental pneumothorax in weanling rabbits with the use of fibrin glue sclerosant. Arch Surg 1986; 121: 565–8.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge the valuable assistance of Susan Zaremba and Marta Barker, MSN, in identifying patients for review.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatal–Perinatal Medicine, University of Connecticut School of Medicine, Farmington, CT, USA

    Shikha Sarkar MD & Naveed Hussain MBBS

  2. Department of Pediatrics, Division of Neonatology, Connecticut Children's Medical Center, 282 Washington Street, Hartford, CT, USA

    Victor Herson MD

Authors
  1. Shikha Sarkar MD
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  2. Naveed Hussain MBBS
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  3. Victor Herson MD
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Additional information

This paper was presented as a poster at the American Academy of Pediatrics meeting, San Francisco, 2001. The authors have no conflict of interest and have no financial obligations to disclose. No reprints requested.

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Sarkar, S., Hussain, N. & Herson, V. Fibrin Glue for Persistent Pneumothorax in Neonates. J Perinatol 23, 82–84 (2003). https://doi.org/10.1038/sj.jp.7210852

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