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Reflections on Errors in Neonatology: II. The “Heroic” Years, 1950 to 1970

Abstract

This series errors in neonatology since the 1920s. Three historical periods are defined: the “Hands-Off” years from 1920 to 1950, the “Heroic” years from 1950 to 1970, and the “Experienced” years from 1970 on. In this article, the “Heroic” years, we discuss the Blossom air lock, sulfisoxazole, chloramphenicol, novobiocin, hexachlorophene, Epsom salts enemas, feeding gastrostomy, diaper laundering, and equipment cleaning.

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References

  1. Silverman WA . Retrolental Fibroplasia: a modern parable. New York: Grune & Stratton, 1980.

    Google Scholar 

  2. Dunn PM . Dr. James Blundell (1790–1878) & neonatal resuscitation. Arch Dis Child 1989;64:494–495.

    CAS  Article  Google Scholar 

  3. Baskett TF, Nagele F . Bernhard Schultze and the swinging neonate. Resuscitation 2001;51:53–56

    Article  Google Scholar 

  4. Kreiselman J . An improved apparatus for treating asphyxia of the newborn infant. Am J Obstet Gyn 1940;39:888–890.

    Article  Google Scholar 

  5. Bloxsom A . Resuscitation of the newborn infant. Use of the positive pressure oxygen-air lock. J Pediatr 1950;37:311–319.

    CAS  Article  Google Scholar 

  6. Kendig JW, Maples PG, Maisels MJ . The Bloxsom air lock: a historical perspective. Pediatrics 2001;108:e116.

    CAS  Article  Google Scholar 

  7. Apgar V, Kreiselman J . Studies on resuscitation. An experimental evaluation of the Bloxsom air-lock. Am J Obstet Gynecol 1953;65:45–52.

    CAS  Article  Google Scholar 

  8. Bloxsom A, Angelique SM . Neonatal infant mortality. Before and after the use of the air lock for the treatment of newborn infants in a large maternity hospital. Am J Obstet Gynecol 1954;67:647–650.

    CAS  Article  Google Scholar 

  9. Reichelderfer TE, Nitowsky HM . A controlled study of the use of the Bloxsom air lock. Pediatrics 1956;18:918–927.

    PubMed  Google Scholar 

  10. Charles D, Larsen B . Streptococcal puerperal sepsis and obstetric infections: A historical perspective. Reviews of Infectious Disease 1986;8:411–422.

    CAS  Article  Google Scholar 

  11. Silverman WA, Andersen DH, Blanc WA, Crozier DN . A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens. Pediatrics 1956;18:614–625

    PubMed  Google Scholar 

  12. O'Dell GB . Studies in kernicterus: I. The protein binding of bilirubin. J Clin Invest 1959;38:823–833.

    CAS  Article  Google Scholar 

  13. Stern L . Drug interaction: II. Drugs, the newborn infant, and the binding of bilirubin to albumin. Pediatrics 1972;49:916–918.

    CAS  PubMed  Google Scholar 

  14. Brodersen R, Robertson A . Chemistry of bilirubin and its interaction with albumin. In: Levine RL, Maisels MJ, editors. eds. Hyperbilirubinemia in the Newborn. Report of the 85th Ross Conference Of Pediatric Research. Columbus: Ross Laboratories; 1983. p. 91–98.

    Google Scholar 

  15. Brodersen R, Robertson A . Ceftriaxone binding to human serum albumin: competition with bilirubin. Molecular Pharmacology 1989;36:478–483.

    CAS  PubMed  Google Scholar 

  16. Woodward TE, Weisman CL . Chloromycetin (Chloramphenicol). In: Antibiotics Monographs. No. 6. New York: Medical Encyclopedia, Inc;1958.

  17. Lietman PS . Chloramphenicol and the neonate — 1979 view. Clinics in Pharmacology 1979;6:151–162.

    CAS  Google Scholar 

  18. Lambdin MA . On the “gray syndrome” and chloramphenicol toxicity. Pediatrics 1960;25:1090.

    Google Scholar 

  19. Sutherland JM . Fatal cardiovascular collapse of infants receiving large amounts of chloramphenicol. Am J Dis Child 1959;97:761–767.

    CAS  Google Scholar 

  20. Kent SP, Wideman GL . Prophylactic antibiotic therapy in infants born after premature rupture of membranes. JAMA 1959;171:1199–1290.

    CAS  Article  Google Scholar 

  21. Burns LE, Hodgman JE, Cass AB . Fatal circulatory collapse in premature infants receiving chloramphenicol. New England J Med 1959;261:1318–1321.

    CAS  Article  Google Scholar 

  22. Buetow KC . An epidemiological approach to the problem of rising neonatal mortality in Baltimore. Am J Public Health 1961;51:217–227.

    CAS  Article  Google Scholar 

  23. Weiss CF, Glazko AJ, Weston JK . Choramphenicol in the newborn infant. A physiological explanation of its toxicity when given in excessive doses. New England J Med 1960;262:787–794.

    CAS  Article  Google Scholar 

  24. Finland M, Nichols RL . Current therapeutics CXIV. Novobiocin. Practitioner 1957;179:84–92.

    CAS  PubMed  Google Scholar 

  25. Sutherland JM, Keller WH . Novobiocin and neonatal hyperbilirubinemia. Am J Dis Child 1961;101:447–453.

    Article  Google Scholar 

  26. Hargreaves T, Holton JB . Jaundice of the newborn due to novobiocin. Lancet 1962;1:839.

    CAS  Article  Google Scholar 

  27. Albert S, Baldwin R, Czekajewski S, van Soestbergen A, Nachman R, Robertson A . Bullous impetigo due to Group II Staphylococcus aureus: an epidemic in a normal newborn nursery. Am J Dis Child 1970;120:10–13.

    CAS  Article  Google Scholar 

  28. Light IJ, Walton LR, Sutherland JM, Shinefield HR, Brackvogel V . Use of bacterial interference to control a staphylococcal nursery outbreak. Am J Dis Child 1967;113:291–300.

    CAS  Article  Google Scholar 

  29. Farquharson CD, Penny SF, Edwards HE, Barr E . The control of staphylococcal skin infections in the nursery. Canad MAJ 1952;67:247–249.

    CAS  Google Scholar 

  30. Gluck L, Wood HF . Effect of an antiseptic skin-care regimen in reducing staphylococcal colonization in newborn infants. N Eng J Med 1961;265:1177–1181.

    CAS  Article  Google Scholar 

  31. Kimbrough RD . Review of the toxicity of hexachlorophene. Arch Environ Health 1971;23:119–122.

    CAS  Article  Google Scholar 

  32. Larsen DL . Studies show hexachlorophene causes burn syndrome. Hospitals J Amer Hosp Assoc 1968;42:63–64

    Google Scholar 

  33. Hart ER . Toxicity of pHisoHex on 90-day skin application to infant rhesus monkeys. Report submitted to Sterling-Winthrop Research Institute by Bionetics Research Laboratories, Dec. 3, 1971.

  34. Curley A, Hawk RE, Kimbrough RD, Nathenson G, Finberg L . Dermal absorption of hexachlorophene in infants. Lancet 1971;2:296–297.

    CAS  Article  Google Scholar 

  35. Plueckhahn VD . Hexachlorophene and skin care of newborn infants. Drugs 1973;5:97–107

    CAS  Article  Google Scholar 

  36. Anonymous. Neuropathology in newborn infants bathed with hexachlorophene. MMWR 1973;22:93–94.

  37. Shuman RM, Leech RW, Alvord EC . Neurotoxicity of hexachlorophene in humans II. A clinicopathological study of 46 premature infants. Arch Neurol 1975;32:320–325.

    CAS  Article  Google Scholar 

  38. Powell H, Swarner O, Gluck L, Lampert P . Hexachlorophene myelinopathy in premature infants. J Pediatr 1973;82:976–981.

    CAS  Article  Google Scholar 

  39. Gowdy JM, Ulsamer AG . Hexachlorophene lesions in newborn infants. Am J Dis Child 1976;130:247–250.

    CAS  PubMed  Google Scholar 

  40. Anderson JM, Cockburn F, Forfar J, Harkness RA, Kelly RW, Kilshaw B . Neonatal spongiform myelinopathy after restricted application of hexachlorophene skin disinfectant. J Clin Pathol 1981;34:25–29.

    CAS  Article  Google Scholar 

  41. Lockhart JD . Hexachlorophene and the Food and Drug Administration. J Clin Pharmacol 1973;13:445–450.

    CAS  PubMed  Google Scholar 

  42. Van Gelder DW . Magnesium sulfate enemas for the respiratory distress syndrome. Pediatrics 1965;35:355–356.

    Google Scholar 

  43. Stowens D . Hyaline membrane disease. Morbid anatomy, hypothesis of its pathogenesis, and suggested method of treatment. Am J Clin Path 1965;44:259–270.

    CAS  Article  Google Scholar 

  44. Andrews BF, Campbell DR, Thomas P . Effects of hypertonic magnesium-sulphate enemas on newborn and young lambs. Lancet 1965;2:64–65.

    Article  Google Scholar 

  45. Outerbridge EW, Papageorgiou A, Stern L . Magnesium sulfate enema in a newborn. Fatal systemic magnesium absorption. JAMA 1973;224:1392–1393.

    CAS  Article  Google Scholar 

  46. Budin P . The Nursling. Edinburgh: The Caxton Publishing, 1907, translated by WJ Maloney.

  47. Royce S, Tepper C, Watson W, Day R . Indwelling polyethylene nasogastric tube for feeding premature infants. Pediatrics 1951;8:79–81.

    CAS  PubMed  Google Scholar 

  48. Tomsovic EJ, Barringer ML, Gay JH, McBride WP, Nomura FM . Feeding gastrostomy in small premature infants. Amer J Dis Child 1966;112:56–60.

    CAS  PubMed  Google Scholar 

  49. Berg RB, Schuster SR, Colodny AH . The use of gastrostomy in feeding premature infants. Pediatrics 1964;33:287–289.

    CAS  PubMed  Google Scholar 

  50. Jones PF, Reid DHS . Gastrostomy in neonatal respiratory failure. Lancet 1966;2:573–574.

    CAS  Article  Google Scholar 

  51. Vengusamy S, Pildes RS, Raffensperger JF, Levine HD, Cornblath M . A controlled study of feeding gastrostomy in low birth weight infants. Pediatrics 1969;43:815–820.

    CAS  PubMed  Google Scholar 

  52. Robson AM, Kissane JM, Elvick NH, Pundavela L . Pentachlorophenol poisoning in a nursery for newborn infants. I. Clinical features and treatment. J Pediatr 1969;75:309–316.

    CAS  Article  Google Scholar 

  53. Anonymous. Pentachlorophenol poisoning in newborn infants — St. Louis, Missouri, April–August 1967. MMWR 1996;45:545–549.

  54. Armstrong RW, Eichner ER, Klein DE, Barthel WF, Bennett JV, Jonsson V, Bruce H, Loveless LE . Pentachlorophenol poisoning in a nursery for newborn infants. II. Epidemiologic and toxicologic studies. J Pediatr 1969;75:317–325.

    CAS  Article  Google Scholar 

  55. Anonymous. Neonatal hyperbilirubinemia, New Jersey, Wyoming. MMWR 1975;24:293–294.

  56. Wysowski DK, Flynt JW, Goldfield M, Altman R, Davis AT . Epidemic neonatal hyperbilirubinemia and use of a phenolic disinfectant detergent. Pediatrics 1978;61:165–170.

    CAS  PubMed  Google Scholar 

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Acknowledgements

I am grateful for the helpful comments and suggestions of Dr. WA Silverman and Dr. Jeffrey P. Baker, and for the extensive grammatical review by Alex F. Robertson IV.

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Robertson, A. Reflections on Errors in Neonatology: II. The “Heroic” Years, 1950 to 1970. J Perinatol 23, 154–161 (2003). https://doi.org/10.1038/sj.jp.7210843

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